Can you split SSD 520-480GB into Boot and Acceleration?

[idata]

Tell me if this is a) Possible and b) Recommended.

Intel DZ77RE-75K Mobo

SATA0: Intel SSD 520 480Gig

SATA1: Any other SATA drive, currently ST32000641AS

I had the idea to install Win7 x64 just shy of 64GB of space for use with IRST acceleration.

Install Win7 on it as the Boot/OS drive.

Add the second spinning HD on SATA1 for programs/data.

Accelerate the spinning drive with IRST.

It seems to me that it would be the best of both worlds.

Can it be done? (before i waste my time)

What is the downside, other than the traditional warnings about SSD potential data failure on C:?

e²

[idata]

...and a followup question...

Any alternate recommendations, like:

Use the Spinning disk as boot/OS/data and accelerate that, then use the remaining partion space (about 383GB) as %TEMP% and expendable data.

e²