Defragging the registry should be equivalent to writing a few MB to the disk, so it has no specific affect on your SSD. As to the value of doing this, like the other posters, I'm not sure.
I posted a similar question weeks ago and got all kinds of flack from the transistor heads, I use a program called Registry Mechanic and been using it for years . I contacted PC Tools the Mfg. And they said it was safe to defrag. the registry, just not the SSD.
